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Published on: April 25, 2025
Alternative bioreactor strategy for probing infection and production
Yu-Chen Hu1, William E Bentley
1Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan.
Abstract:
Probing the baculovirus infection process is essential in optimizing the recombinant protein production. Typically, researchers monitor the infection process in the stirred tank reactor, which, however, contains a population of cells infected at different times after virus inoculation. This chapter describes a two-stage reactor system consisting of an upstream continuous stirred tank reactor and a downstream tubular reactor with segmented plug flow for probing baculovirus infection and production.
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