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Related Experiment Video

Updated: Jul 10, 2026

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

Noonan syndrome: a case report.

S Asokan¹, M S Muthu, V Rathna Prabhu

¹Dept. of Pediatric Dentistry, Meenakshi Ammal Dental College, Chennai, Tamil Nadu, India. asokansharath@yahoo.com

Journal of the Indian Society of Pedodontics and Preventive Dentistry

|October 24, 2007

Summary

Noonan syndrome, a genetic disorder affecting 1 in 1,000-2,500 children, presents with distinct facial features and developmental issues. This case highlights the crucial role of pediatric dentists in leading multidisciplinary teams for comprehensive patient care.

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Last Updated: Jul 10, 2026

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

Area of Science:

Genetics and Developmental Biology
Pediatric Dentistry
Clinical Case Reports

Background:

Noonan syndrome is a genetic disorder with varied inheritance patterns, affecting approximately 1 in 1,000-2,500 children.
Key features include facial dysmorphia, short stature, cardiac anomalies, and skeletal malformations, impacting overall development.
Early diagnosis and intervention are crucial for managing the complex health needs associated with Noonan syndrome.

Observation:

A 13-year-old girl diagnosed with Noonan syndrome was referred for specialized dental management.
The patient presented with orofacial and occlusal defects requiring comprehensive dental rehabilitation.
Initial dental care was provided by a general dental practitioner, followed by referral to a pediatric dentist.

Findings:

The case report details the full mouth dental rehabilitation of a pediatric patient with Noonan syndrome.
Correction of orofacial and occlusal anomalies was a primary focus of the treatment.
The patient's case underscores the need for specialized dental interventions in managing Noonan syndrome.

Implications:

Multidisciplinary treatment approaches are essential for optimizing outcomes in children with Noonan syndrome.
Pediatric dentists are pivotal in leading healthcare teams to address the multifaceted challenges of this condition.
This case emphasizes the significant contribution of dental professionals to the holistic care and management of individuals with Noonan syndrome.