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Updated: Jul 10, 2026
09:45
Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines
Published on: August 21, 2019
Cell adhesion-mediated radioresistance revisited
1OncoRay - Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.
International Journal of Radiation Biology
|October 24, 2007
Summary
Cell adhesion via integrins influences tumor cell response to radiation, contributing to radioresistance. Targeting these cell-matrix interactions could lead to new radiotherapy strategies.
Area of Science:
- Cell biology
- Radiotherapy research
- Cancer therapy
Background:
- Integrin-mediated cell adhesion to extracellular matrix proteins influences cellular responses.
- This interaction is implicated in the development of radiation and chemoresistance in tumor cells.
Purpose of the Study:
- To review and summarize the role of cell adhesion-mediated radioresistance (CAM-RR).
- To explore how integrin-mediated adhesion impacts cellular response to ionizing radiation.
Main Methods:
- A comprehensive literature search of the PubMed database was conducted.
- Data were synthesized focusing on the mechanisms of cell adhesion-mediated radioresistance.
Main Results:
- Integrins and associated signaling pathways, along with receptor tyrosine kinases, activate defense mechanisms.
- These mechanisms hinder the effective eradication of tumor cells through radiotherapy.
Conclusions:
- Understanding focal adhesions, the multiprotein complexes mediating cell-matrix interactions, is crucial.
- Identifying differences between normal and tumor cells within these interactions may enable novel targeted radiotherapy approaches.
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