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Updated: Jul 10, 2026
Retroductal Nanoparticle Injection to the Murine Submandibular Gland
Published on: May 3, 2018
[Research on thymopentin-loaded N-trimethyl chitosan nanoparticles administered through mouth]
Shi-wei Tang1, Xiao-jia Yuan, Zhi-rong Zhang
1Key Laboratory of Drug Targeting, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Objective:
To prepare a peroral thymopentin-loaded N-trimethyl chitosan chloride-nanoparticle (Tp5-TMC-NP) ,and observe the pharmacodynamic action when the Tp5-TMC-NP is taken by way of the mouth.
Methods:
N-trimethyl chitosan chloride was first synthesized, and then Tp5-TMC-NP was prepared with the formulation technology optimized by the Central Composite Design. The influence of Tp5-TMC-NP on the ratio of CD4+/CD8+ of T-lymphocytes were determined by flow cytometer.
Results:
The regular global Tp5-TMC-NP prepared with the optimized formulation craft had the mean diameter of 110.6 nm and got the entrapment efficiency of 78.8%. The ratio of lymphocyte CD4+/CD8+ of Wistar rat administered with Tp5-TMC-NP perfusing stomach had 2.59 times higher than that with Tp5.
Conclusion:
Taken orally the Tp5-TMC-NP has much higher efficiency than Tp5.