Related Experiment Video
Updated: Jul 10, 2026

Fertility Preservation in Patients with Severe Ovarian Dysfunction
Published on: March 25, 2021
Triplet pregnancy after ovulation induction with an aromatase inhibitor
Cary L Dicken1, Gary S Nakhuda, Michael M Guarnaccia
1Department of Obstetrics and Gynecology, Center for Women's Reproductive Care, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.
Objective:
To describe the first reported case of a triplet pregnancy subsequent to the use of an aromatase inhibitor for ovulation induction.
Design:
Case report.
Setting:
Academic medical center.
Patient(S):
A 32-year-old female with polycystic ovary syndrome and primary infertility.
Intervention(S):
Letrozole, 5 mg/day, on cycle days 2 to 6 for ovulation induction.
Main Outcome Measure(S):
Clinical pregnancy.
Result(S):
Viable triplet gestation.
Conclusion(S):
Use of an aromatase inhibitor for ovulation induction does not eliminate the risk for higher order multiple pregnancy.
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