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10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Uncontrolled headache induced by oxcarbazepine
Elcio Juliato Piovesan1, Helio Ghizoni Teive, Luciano de Paola
1Headache Clinic, Neurology Service, Department of Internal Medicine, Hospital de Clínicas, Federal University of Paraná, Rua General Carneiro 181, 120 andar, sala 1236, CEP-80060-900, Curitiba-Paraná, Brazil. piovesan@avalon.sul.com.br
The Journal of Headache and Pain
|October 24, 2007
Summary
Oxcarbazepine (OXC) can trigger severe, intractable headaches, specifically status migrainosus, in patients with pre-existing migraine and epilepsy. Discontinuing OXC was necessary for symptom resolution, highlighting a potential idiosyncratic drug reaction.
Area of Science:
- Neurology
- Pharmacology
Background:
- Drug-induced headaches are idiosyncratic side effects, often linked to metabolic imbalances.
- Primary headaches may be more susceptible to these reactions or evolve into uncontrolled states.
Observation:
- Three patients with controlled migraine and epilepsy developed status migrainosus after switching from carbamazepine to oxcarbazepine (OXC).
- Intractable headaches emerged 24-72 hours post-switch, unresponsive to symptomatic treatments.
Findings:
- Oxcarbazepine (OXC) introduction precipitated status migrainosus in susceptible patients.
- Complete headache symptom recovery occurred solely after OXC discontinuation.
Implications:
- This suggests an idiosyncratic reaction to oxcarbazepine causing severe headache exacerbation.
- Understanding OXC's role in drug-induced headaches and status migrainosus is crucial for patient management.
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