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Updated: Jul 10, 2026
A Rat Model of Pouchitis Following Proctocolectomy and Ileal Pouch-Anal Anastomosis Using Dextran Sulfate Sodium
Published on: May 31, 2024
[Long term functional outcomes after ileoanal pouch in patients with and without postoperative complications]
Ubaldo Gualdrini1, Mariana Coraglio, Laura Filippa
1Unidad de Proctologia, Hospital de Gastroenterología, Dr Carlos Bonorino Udaondo, Ciudad Autónoma de Buenos Aires, Argentina. uagualdrini@fibertel.com.ar
Background:
the proctocolectomy with ilealpouch (IP) has become the gold standard for surgical treatment for ulcerative colitis (UC). The postoperative complications are frequent but the definitive outcome is acceptable.
Aim:
our aim was to evaluate the long term functional outcome in a series of consecutive patients with IP and to establish its relation with postoperative complications.
Patients And Methods:
we included 144 patients categorized in two groups: I--patients without postoperative complications (n: 71); II--patients with postoperative complications (n: 73). Patients were followed for a median time of 3.8 years (range 1-15). We evaluated: stool frequency, anal discrimination between gas and stool, voluntary evacuation inhibition, requirement of antidiarrheal medications and presence of incontinence.
Results:
the functional outcome was similar between the two groups in terms of stool fequency medication use, anal discrimination and the voluntary inhibition of evacuation for more than 5 hours. A trend to present seepage was seen in patients with complications (34%) more than in those without them (20%; p<0.08 NS). Compared with group II, seepage in group I was significantly related with dietary lapses (p<0.01). The most frequent complication in incontinent patients was pelvic sepsis (56%).
Conclusions:
our study showed that most of long-term functional parameters are not influenced by the presence of postoperative complications. However, a trend for incontinence seems to be related to postoperative complications, more frequently with pelvic sepsis.
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