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Updated: Jul 10, 2026
Characterizing Mammalian Zinc Transporters Using an In Vitro Zinc Transport Assay
Published on: June 2, 2023
Highly sensitive fluorescent probes for zinc ion based on triazolyl-containing tetradentate coordination motifs
Sha Huang1, Ronald J Clark, Lei Zhu
1Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306-4390, USA.
Abstract:
Two new 1,2,3-triazolyl-containing N4-tetradentate ligands show nanomolar affinity for Zn2+ under physiological conditions. Furthermore, they are easily derivatizable to afford fluorescent probes suitable for sensitive Zn2+ detection. Structural characterizations in both solid and solution states suggest that N3 and N2 in the 1,2,3-triazolyl moiety coordinate with Zn2+ in A and B to afford five-membered and six-membered coordination rings, respectively. The probes show sensitive fluorescence enhancement and ratiometric responses to Zn2+.
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