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Related Experiment Video

Updated: Jul 10, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

Melatonin expression in periodontal disease.

G Gómez-Moreno¹, A Cutando-Soriano, C Arana

¹Department of Special Care in Dentistry, School of Dentistry, University of Granada, Granada, Spain.

Journal of Periodontal Research

|October 25, 2007

Summary

Periodontal disease is linked to lower melatonin levels. Melatonin may protect against periodontal infection, with levels fluctuating based on disease severity.

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Isolation, Processing and Analysis of Murine Gingival Cells

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Published on: July 2, 2013

Area of Science:

Immunology
Endocrinology
Oral Health

Background:

Periodontal disease is a common inflammatory condition affecting the gums and supporting structures of the teeth.
Melatonin, a hormone primarily known for regulating sleep-wake cycles, also possesses antioxidant and anti-inflammatory properties.

Purpose of the Study:

To investigate the association between periodontal disease and circulating melatonin levels.
To explore the relationship between melatonin levels and the severity of periodontal disease.

Main Methods:

A case-control study involving 46 patients with periodontal disease and 26 healthy controls.
Assessment of periodontal status using the Community Periodontal Index.
Measurement of plasma and salivary melatonin levels via radioimmunoassay and analysis of lymphocyte subpopulations using flow cytometry.

Main Results:

Patients with periodontal disease exhibited significantly lower plasma and salivary melatonin levels compared to healthy controls.
A biphasic relationship was observed between plasma melatonin and periodontal disease severity.
Increased CD4+ T-cell counts correlated with worsening periodontal disease and altered melatonin levels.

Conclusions:

Melatonin may play a protective role in combating periodontal infections.
Further research is warranted to elucidate the precise mechanisms and therapeutic potential of melatonin in periodontal health.