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Updated: Jul 10, 2026
03:26
Detrusor Underactivity Model in Rats by Conus Medullaris Transection
Published on: August 28, 2020
Neobladder overactivity; an equivalent to spontaneous rectal contraction
Ryuji Sakakibara1, Yusuke Awa, Yukio Naya
1Neurology Division, Department of Internal Medicine, Sakura Medical Center, Toho University, 564-1 Shimoshizu, Sakura, Japan. sakakibara@sakuta.med.toho-u.ac.jp
Summary
Severe nocturnal enuresis after ileal neobladder surgery was linked to neobladder overactivity and decreased sensation. Bowel-targeted management may help reduce nighttime wetting in these patients.
Area of Science:
- Urology
- Gastroenterology
Background:
- Orthotopic ileal neobladder reconstruction is a surgical option for bladder cancer.
- Nocturnal enuresis is a potential complication following this procedure.
Observation:
- Videomanometry revealed significant neobladder overactivity (up to 50 cmH2O) during slow filling.
- Rectal manometry showed normal activity (up to 20 cmH2O) and sensation.
- The patient experienced markedly decreased neobladder sensation compared to rectal sensation.
Findings:
- Neobladder overactivity, similar to rectal phasic contractions, was observed.
- Reduced neobladder sensation contributed to nocturnal enuresis.
- Voiding involved strain and overactivity, mirroring rectal voiding patterns, despite preserved urethral sphincter function.
Implications:
- Nocturnal enuresis in ileal neobladder patients may stem from detrusor overactivity and sensory deficits.
- Bowel-targeted management strategies could be beneficial for managing nocturnal enuresis.
- Further research into neobladder dynamics and sensory feedback is warranted.
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