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Related Concept Videos

Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Rheumatic Heart Disease IV: Nursing Management01:20

Rheumatic Heart Disease IV: Nursing Management

AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...

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Related Experiment Video

Updated: Jul 10, 2026

Pulsed Wave Doppler Assessment of Diastolic Dysfunction in the ZSF-1 Rat Model of Pulmonary Hypertension Due to Left Heart Disease
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Diastolic heart function in RA patients.

M Wislowska1, B Jaszczyk, M Kochmański

  • 1Department of Rheumatology, Central Clinical Hospital, Wołoska 137, 02-507 Warsaw, Poland. mwislowska@wp.pl

Rheumatology International
|October 25, 2007
PubMed
Summary
This summary is machine-generated.

Rheumatoid arthritis (RA) patients show increased left ventricular (LV) mass and diastolic dysfunction, even without apparent heart disease. Early detection via echocardiography is crucial for managing cardiovascular risks in RA.

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Area of Science:

  • Cardiology
  • Rheumatology
  • Medical Imaging

Background:

  • Rheumatoid arthritis (RA) is associated with an elevated risk of cardiovascular disease (CVD), including atherosclerosis and congestive heart failure (CHF).
  • Subclinical myocardial dysfunction, characterized by elevated inflammatory markers like IL-6, CRP, and TNF alpha, is common in RA and CHF.
  • Left ventricular (LV) diastolic dysfunction is a primary mechanism for heart failure development, often remaining asymptomatic.

Purpose of the Study:

  • To evaluate left ventricular (LV) systolic and diastolic functions in rheumatoid arthritis (RA) patients using pulsed Doppler echocardiography.
  • To identify subclinical cardiovascular abnormalities in RA patients without clinically evident heart disease.
  • To correlate RA duration and severity with the degree of LV diastolic dysfunction.

Main Methods:

  • Pulsed Doppler echocardiography was employed to assess LV systolic and diastolic functions.
  • Echocardiographic measurements were compared between RA patients and a control group of healthy volunteers.
  • Analysis included left ventricular mass index, wall thickness, aortic root diameter, ejection fraction, isovolumetric relaxation time, and deceleration time.

Main Results:

  • RA patients exhibited significantly increased LV mass index, interventricular septum thickness, LV posterior wall thickness, and aortic root diameter compared to controls.
  • Ejection fraction was significantly lower in the RA group. Diastolic function parameters showed prolonged isovolumetric relaxation time and shortened deceleration time in RA patients.
  • Valvular heart disease was significantly more prevalent in RA patients (80%) than in controls (20%).

Conclusions:

  • Rheumatoid arthritis patients demonstrate significant subclinical left ventricular structural and functional abnormalities, including diastolic dysfunction, even without overt cardiovascular symptoms.
  • Echocardiography is valuable for detecting early cardiac changes in RA patients, aiding in cardiovascular risk assessment.
  • The study highlights the importance of monitoring cardiac health in RA patients due to increased prevalence of valvular heart disease and LV dysfunction.