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Related Concept Videos

Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

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Related Experiment Video

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A Rat Model of Compound Acne
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Published on: November 1, 2024

Acne arising in an epidermal nevus.

Chad M Hivnor1, Albert C Yan, Paul J Honig

  • 1Nellis Air Force Base, Nevada 89191, USA. Chad.Hivnor@nellis.af.mil

Pediatric Dermatology
|October 26, 2007
PubMed
Summary

Acne developed exclusively within a congenital epidermal nevus during puberty. This case highlights genetic mosaicism affecting pilosebaceous units in skin development.

Area of Science:

  • Dermatology
  • Genetics
  • Developmental Biology

Background:

  • Epidermal nevi are benign congenital skin growths following Blaschko lines.
  • These lesions exhibit diverse histologic patterns, including hamartomatous hyperplasia of epidermal and adnexal structures.

Observation:

  • A rare case of acne vulgaris exclusively manifesting within a preexisting keratinocytic epidermal nevus is reported.
  • The onset of acne occurred during puberty in the affected nevus.

Findings:

  • This presentation suggests localized pilosebaceous unit involvement within the epidermal nevus.
  • The findings provide evidence for genetic mosaicism influencing the development and function of these units.

Implications:

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  • This case expands the understanding of epidermal nevi and their potential to develop specific conditions.
  • It offers insights into the role of genetic mosaicism in localized pilosebaceous unit abnormalities and acne pathogenesis.