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Design and evaluation of anacardic acid derivatives as anticavity agents
Ivan R Green1, Felismino E Tocoli, Sang Hwa Lee
1Department of Chemistry, University of the Western Cape, P/Bag X17, Bellville, 7530, South Africa. igreen@uwc.ac.za
Abstract:
On the basis of antibacterial anacardic acids, 6-pentadecenylsalicylic acids, isolated from the cashew apple, Anacardium occidentale L. (Anacardiaceae), a series of 6-alk(en)ylsalicylic acids were synthesized and tested for their antibacterial activity against Streptococcus mutans ATCC 25175. Among them, 6-(4',8'-dimethylnonyl)salicylic acid was found to exhibit the most potent antibacterial activity against this cariogenic bacterium with the minimum inhibition concentration (MIC) of 0.78 microg/ml.
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