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Bilateral striatal necrosis, dystonia and multiple mitochondrial DNA deletions: case study and effect of deep brain
Maria Stella Aniello1, Davide Martino, Vittoria Petruzzella
1Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy.
Abstract:
Bilateral striatal necrosis (BSN) is relatively rare and has been related to a wide array of causes, including nuclear and mitochondrial DNA mutations. We report the clinical vignette of a patient with a 37 year-history of generalized dystonia secondary to BSN associated with multiple mitochondrial DNA deletions of undefined origin. Globus pallidus interna deep brain stimulation produced sustained benefit, with predominant improvements in disability.
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