[Experimental data on the biological effect of nickel and lead contained in the drinking water acting in combination]

During one year toxicological experiment on white male rats, receiving simultaneously per os nickel in doses 0.005 mg/kg and lead in doses 0.0025 mg/kg, equivalent respectively to the recommended by CMEA norms for nickel and hygienic norm for lead in potable waters, as well as nickel and lead in doses 0.015 and 0.01 mg/kg. 0.15 and 0.1 mg/kg, surpassing 3 and 4 times and 30 and 40 times the norms or only nickel in doses 0.015 mg/kg, are studied for some sides of their biological effect. The following indices are examined: blood sugar lactatedehydrogenase, sodium, and potassium in the serum; haemoglobin, erythrocytes, reticulocytes and deltaaminlevulinatdehydrase activity in blood; glycoso-6-phosphatdehydrogenase in heart. It is already established, that in chronic combined oral influence with nickel and lead respectively in doses 0.15 and 0.1 mg/kg and 0.015 and 0.01 mg/kg is disturbed the carbohydrate metabolism, the electrolyte balance and the hemapoiesis, and in doses 0.005 and 0.0025 mg/kg no changes are established according to all examined indices. The nickel in doses 0.015 mg/kg at independent effect also leads to disturbance of the electrolyte, reticulocytic and erythrocytic metabolism.