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Updated: Jul 10, 2026
10:26
RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
Published on: March 11, 2014
[Cutaneous squamous cell carcinoma and human papillomavirus]
R Corbalán-Vélez1, J A Ruiz-Maciá, C Brufau
1Servicio de Dermatología. Hospital Universitario Virgen Arrixaca. Murcia. España. raulcorb@gmail.com
Actas Dermo-Sifiliograficas
|October 27, 2007
Summary
Human papillomavirus (HPV) is linked to cervical and anogenital cancers. Emerging evidence suggests HPV also contributes to cutaneous squamous cell carcinoma (SCC), especially with UV exposure and immunosuppression, potentially worsening prognosis.
Area of Science:
- Oncology
- Virology
- Dermatology
Context:
- The association between human papillomavirus (HPV) and cervical/anogenital cancers is established.
- Links between HPV and cutaneous squamous cell carcinoma (SCC) are less understood.
- Epidermodysplasia-verruciformis-associated HPV is implicated in extragenital SCC, affecting both immunocompromised and immunocompetent individuals.
Purpose:
- To review the oncogenic mechanisms of mucosal and epidermodysplasia-verruciformis-associated HPV.
- To explore the interplay between HPV, immunosuppression, and UV radiation in SCC development.
- To discuss the potential prognostic implications of HPV in SCC.
Summary:
- Mucosal HPV types are increasingly linked to cervical and anogenital squamous cell carcinomas (SCCs).
- Epidermodysplasia-verruciformis-associated HPV is associated with extragenital cutaneous SCCs.
- Combined factors of HPV, immunosuppression, and UV radiation likely drive SCC development, with HPV potentially indicating a poorer prognosis and increased metastasis risk.
Impact:
- Highlights HPV's broader role in various SCC types beyond mucosal sites.
- Suggests a multifactorial etiology for SCC involving viral, host, and environmental factors.
- Informs clinical practice regarding SCC risk stratification and management, considering HPV status.
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