Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Atopy and autoimmunity -- a case report].

M Alfaro1, F Tapadinhas, Am Neves

  • 1Interna(o) do Internato Complementar de Pediatria do Hospital Distrital de Faro. pediatria@hdfaro.min-saude.pt

Revista Portuguesa De Pneumologia
|October 27, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neuroprotective Effects of Dexamethasone in a Neuromelanin-Driven Parkinson's Disease Model.

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology·2024
Same author

The impact of bedside wipes in multi-patient rooms: a prospective, crossover trial evaluating infections and survival.

The Journal of hospital infection·2023
Same author

101 <i>Dothideomycetes</i> genomes: A test case for predicting lifestyles and emergence of pathogens.

Studies in mycology·2020
Same author

Examination of failed retrieved temporomandibular joint (TMJ) implants.

Acta biomaterialia·2016
Same author

SECOND LATIN AMERICAN INTERCOMPARISON ON INTERNAL DOSE ASSESSMENT.

Radiation protection dosimetry·2015
Same author

Quality control of leather by terahertz time-domain spectroscopy.

Applied optics·2015
Same journal

Environment and Health in Children Day Care Centres (ENVIRH) - Study rationale and protocol.

Revista portuguesa de pneumologia·2020
Same journal

H1N1 infection and acute respiratory failure: Can we give non-invasive ventilation a chance?

Revista portuguesa de pneumologia·2020
Same journal

[Acute fibrinous and organizing pneumonia].

Revista portuguesa de pneumologia·2020
Same journal

The role of infection in asthma.

Revista portuguesa de pneumologia·2020
Same journal

Erratum to "Wood Charcoal Dust Pneumoconiosis".

Revista portuguesa de pneumologia·2017
Same journal

The role of Bronchoalveolar lavage in Interstitial Lung Diseases.

Revista portuguesa de pneumologia·2017
See all related articles

This case study highlights a teenager with both atopy (allergic reactions) and autoimmunity, suggesting a potential link between these distinct immune system dysfunctions. The findings emphasize a possible global immune impairment rather than a mere statistical association.

Area of Science:

  • Immunology
  • Clinical Medicine
  • Genetics

Background:

  • Atopy and autoimmunity are traditionally viewed as separate immune responses.
  • Emerging research suggests shared underlying pathogenic mechanisms.
  • Understanding these connections is crucial for diagnosing and managing complex immune disorders.

Observation:

  • A teenager presented with a history of recurrent respiratory infections, pneumonia, and later developed atopy markers (elevated IgE, positive RAST, skin sensitivity).
  • The patient also exhibited circulating immune complexes and deficiencies in IgG subclasses (IgG2, IgG3, IgG4).
  • Notably, the patient shared the HLA-B8 antigen with her mother, who had a history of asthma and myasthenia gravis.

Findings:

  • Despite initial negative atopy markers, comprehensive testing confirmed atopy.

Related Experiment Videos

  • The patient's immune profile revealed a complex dysfunction involving both atopic and autoimmune features.
  • The simultaneous presentation of atopy and autoimmune-related conditions, alongside specific genetic markers, points towards a systemic immune impairment.

    • Implications:

    • This case underscores the potential for a shared pathway between atopy and autoimmunity, challenging classical distinctions.
    • It suggests that certain immune dysfunctions may manifest with diverse hypersensitivity reactions.
    • Further research into these overlapping mechanisms could lead to novel diagnostic and therapeutic strategies for immune-mediated diseases.