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Comparison of different dry binders for roll compaction/dry granulation.
Michael G Herting1, Kirsten Klose, Peter Kleinebudde
1Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University, Duesseldorf, Germany.
Pharmaceutical Development and Technology
|October 27, 2007
Summary
Small particle copovidone and crospovidone binders enhance tablet properties during dry granulation. Small crospovidone is ideal for uncoated tablets, offering superior binding, disintegration, and dissolution.
Area of Science:
- Pharmaceutical Technology
- Materials Science
Background:
- Dry granulation and roll compaction are critical pharmaceutical manufacturing processes.
- Binder selection significantly impacts granule properties and final tablet characteristics.
Purpose of the Study:
- To evaluate the suitability of various dry binders for roll compaction/dry granulation.
- To compare the performance of copovidones, crospovidones, and celluloses as binders.
Main Methods:
- Comparative analysis of two copovidones and two crospovidones against three celluloses.
- Assessment of binder performance in binary mixtures and drug-containing formulations.
- Evaluation of tablet tensile strength and dissolution properties.
Main Results:
- Small particle copovidone and crospovidone demonstrated superior binding, yielding larger granules, reduced fine particles, and higher tensile strength.
- Significant differences in dissolution rates were observed between the binders.
- Tablets with small copovidone exhibited slower dissolution compared to those with small crospovidone.
Conclusions:
- Small crospovidone is the most suitable binder for uncoated tablets due to its excellent dry binding, rapid disintegration, and fast dissolution.
- Binder particle size is a key factor influencing granule properties and tablet performance.
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