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Updated: Jul 10, 2026

A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers
Published on: January 5, 2018
The DYD-RCT protocol: an on-line randomised controlled trial of an interactive computer-based intervention compared
Elizabeth Murray1, Jim McCambridge, Zarnie Khadjesari
1E-health Unit, Department of Primary Care and Population Sciences, University College London, Highgate Hill, London N19 5LW, UK. elizabeth.murray@pcps.ucl.ac.uk
Background:
Excessive alcohol consumption is a significant public health problem throughout the world. Although there are a range of effective interventions to help heavy drinkers reduce their alcohol consumption, these have little proven population-level impact. Researchers internationally are looking at the potential of Internet interventions in this area.
Methods/Design:
In a two-arm randomised controlled trial, an on-line psychologically enhanced interactive computer-based intervention is compared with a flat, text-based information web-site. Recruitment, consent, randomisation and data collection are all on-line. The primary outcome is total past-week alcohol consumption; secondary outcomes include hazardous or harmful drinking, dependence, harm caused by alcohol, and mental health. A health economic analysis is included.
Discussion:
This trial will provide information on the effectiveness and cost-effectiveness of an on-line intervention to help heavy drinkers drink less.
Trial Registration:
International Standard Randomised Controlled Trial Number Register ISRCTN31070347.
