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Updated: Jul 10, 2026
05:45
Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality
Published on: April 7, 2023
Process design applied to optimise a directly compressible powder produced via a continuous manufacturing process
Y Gonnissen1, S I V Gonçalves, B G De Geest
1Laboratory of Pharmaceutical Technology, Ghent University, Ghent, Belgium.
Summary
Spray drying creates ready-to-compress acetaminophen powder mixtures without extra steps. Optimal conditions yielded high process efficiency and excellent powder properties for direct compression tablet manufacturing.
Area of Science:
- Pharmaceutical Technology
- Materials Science
Background:
- Direct compression offers an efficient method for tablet manufacturing.
- Traditional direct compression requires multiple processing steps, impacting efficiency.
Purpose of the Study:
- To develop 'ready-to-compress' powder mixtures using co-spray drying.
- To optimize spray drying parameters for improved powder properties and process yield.
Main Methods:
- Co-spray drying of acetaminophen, mannitol, erythritol, maltodextrin, crospovidone, colloidal silicon dioxide, and polyoxyethylene 20 sorbitan monooleate.
- Experimental design to evaluate processibility, physico-chemical properties, and compactability.
- Numerical optimization to determine ideal spray drying conditions.
Main Results:
- A feed suspension with 27.2% solids content showed high yield, flowability, and short disintegration time.
- Regression models demonstrated significant effects of temperature on powder properties and yield.
- Optimal spray drying parameters (221°C inlet, 81°C outlet, 6 bar atomization) were identified.
Conclusions:
- Co-spray drying is a viable method for producing 'ready-to-compress' powder mixtures.
- Optimized spray drying parameters enhance process yield and powder characteristics for direct compression.
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