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Fourth-generation fluoroquinolone-resistant mycobacterial keratitis after laser in situ keratomileusis
Majid Moshirfar1, Jay J Meyer, Ladan Espandar
1John A. Moran Eye Center, Department of Ophthalmology, University of Utah, Salt Lake City, Utah 84121, USA. Majid.Moshirfar@hsc.utah.edu
Abstract:
We report a case of mycobacterial keratitis resistant to fourth-generation fluoroquinolones after laser in situ keratomileusis (LASIK) with fourth-generation fluoroquinolone prophylaxis. While receiving moxifloxacin post LASIK, the patient was diagnosed with moxifloxacin-resistant Mycobacterium chelonae keratitis. Culture susceptibilities revealed isolates resistant to moxifloxacin and gatifloxacin, and treatment with topical amikacin and clarithromycin with oral doxycycline and clarithromycin along with flap amputation was necessary to control the infection. This case demonstrates the potential limitations in the coverage of these antibiotic agents.
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