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Related Concept Videos

Hair Cells01:22

Hair Cells

Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
The Cochlea01:13

The Cochlea

The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.

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Related Experiment Video

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Isolation and Culture of Primary Cochlear Hair Cells from Neonatal Mice
06:07

Isolation and Culture of Primary Cochlear Hair Cells from Neonatal Mice

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New insights into peripherin expression in cochlear neurons.

F Lallemend1, R Vandenbosch, S Hadjab

  • 1Research Center for Cellular and Molecular Neurobiology, Developmental Neurobiology Unit, University of Liège, Av. de l'Hopital 1 (B36), 4000 Liège, Belgium. francois.lallemend@ki.se <francois.lallemend@ki.se>

Neuroscience
|October 30, 2007
PubMed
Summary
This summary is machine-generated.

Peripherin protein expression in cochlear neurons changes during development and is re-expressed after nerve injury, suggesting a role in axonal growth and regeneration.

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Area of Science:

  • Neuroscience
  • Cell Biology
  • Developmental Biology

Background:

  • Peripherin is an intermediate filament protein in peripheral and enteric neurons.
  • Its function in cochlear neurons, particularly type II neurons, remains largely unknown.
  • Peripherin expression is linked to axonal growth and nerve regeneration in other systems.

Purpose of the Study:

  • To investigate the developmental expression pattern of peripherin in rat cochlear neurons.
  • To determine if peripherin expression is modified following nerve injury.
  • To elucidate the role of peripherin in cochlear neuron development and regeneration.

Main Methods:

  • Comparative analysis of peripherin and beta III-tubulin expression from embryonic to adult stages in rat cochlea.
  • Investigation of peripherin expression in axotomized cochlear neurons using organotypic explant models.
  • Study of protein expression and localization in dissociated cochlear neuron cultures.

Main Results:

  • Peripherin is initially expressed in all cochlear neurons but becomes restricted to type II neurons postnatally.
  • Beta III-tubulin shows differential cell body expression in type I neurons from postnatal day 10.
  • Axotomy induces re-expression of peripherin in a majority of cochlear neurons.
  • Peripherin is abundant in growth cones during regeneration, unlike beta III-tubulin.

Conclusions:

  • Peripherin expression is dynamic in cochlear neurons, not a static trait.
  • Peripherin likely plays a crucial structural role in cochlear neuron development and regeneration.
  • Developmentally regulated factors, like peripherin, are reactivated during neuronal repair.