Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nervous Tissue: Myelin01:25

Nervous Tissue: Myelin

The myelin sheath is a multilayered lipid and protein covering that insulates the axon of a neuron, enhancing the speed of nerve impulse conduction. Axons without this sheath are referred to as unmyelinated. Two types of neuroglia, Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS) are responsible for producing myelin sheaths.
Schwann cells begin to form myelin sheaths around axons during fetal development. They wrap around a small...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neurovascular dysfunction in the development and progression of neuroinflammatory diseases.

Frontiers in cellular neuroscience·2026
Same author

Nef mediates neuroimmune response, myelin impairment, and neuronal injury in EcoHIV-infected mice.

Life science alliance·2024
Same author

Extracellular vesicles produced by HIV-1 Nef-expressing cells induce myelin impairment and oligodendrocyte damage in the mouse central nervous system.

Journal of neuroinflammation·2024
Same author

A phenotypic screening platform for identifying chemical modulators of astrocyte reactivity.

Nature neuroscience·2024
Same author

Isolation of Pure Astrocytes and Microglia from the Adult Mouse Spinal Cord For In Vitro Assays and Transcriptomic Studies.

Journal of visualized experiments : JoVE·2023
Same author

A unique cell population expressing the Epithelial-Mesenchymal Transition-transcription factor Snail moderates microglial and astrocyte injury responses.

PNAS nexus·2023

Related Experiment Video

Updated: Jul 10, 2026

Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin
08:57

Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin

Published on: March 26, 2015

Dissecting demyelination.

Robert H Miller1, Sha Mi

  • 1Center for Translational Neuroscience, Department of Neuroscience, 10900 Euclid Avenue, Case Western Reserve University, Cleveland, Ohio 44106, USA. rhm3@case.edu

Nature Neuroscience
|October 30, 2007
PubMed
Summary

Myelin repair failure in multiple sclerosis (MS) hinders central nervous system (CNS) recovery. Successful repair mirrors developmental myelination, while failures stem from disrupted sequential stages, offering therapeutic targets.

Area of Science:

  • Neuroscience
  • Demyelinating Diseases
  • Regenerative Medicine

Background:

  • Central nervous system (CNS) myelin loss and impaired remyelination by oligodendrocytes cause functional deficits in diseases like multiple sclerosis (MS).
  • The reasons for remyelination failure in MS remain largely unknown.
  • Advances in understanding oligodendrocyte development and successful remyelination offer potential therapeutic strategies.

Purpose of the Study:

  • To propose a framework for understanding myelin repair failure in demyelinating diseases.
  • To identify critical stages and rate-limiting steps in the myelin repair process.
  • To provide insights for developing targeted therapeutic interventions.

Main Methods:

  • Conceptual analysis of developmental myelination processes.

More Related Videos

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Isolation of Mouse Primary Microglia by Magnetic-Activated Cell Sorting in Animal Models of Demyelination
04:53

Isolation of Mouse Primary Microglia by Magnetic-Activated Cell Sorting in Animal Models of Demyelination

Published on: April 5, 2022

Related Experiment Videos

Last Updated: Jul 10, 2026

Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin
08:57

Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin

Published on: March 26, 2015

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Isolation of Mouse Primary Microglia by Magnetic-Activated Cell Sorting in Animal Models of Demyelination
04:53

Isolation of Mouse Primary Microglia by Magnetic-Activated Cell Sorting in Animal Models of Demyelination

Published on: April 5, 2022

  • Comparison of successful and unsuccessful remyelination sequences.
  • Identification of potential bottlenecks in myelin repair.

    • Main Results:

    • Successful myelin repair in the adult CNS is proposed to recapitulate developmental myelination stages.
    • Failure in myelin repair is hypothesized to result from disruptions in critical sequential events.
    • Specific rate-limiting steps and vulnerable aspects at each stage can be defined.

    Conclusions:

    • Understanding the sequential nature of myelin repair is crucial for identifying therapeutic targets in demyelinating diseases.
    • Interventions should aim to address specific, perturbed stages of the myelin repair process.
    • Targeting rate-limiting steps offers a logical approach for promoting CNS remyelination in MS.