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Mass Spectrometry and Luminogenic-based Approaches to Characterize Phase I Metabolic Competency of In Vitro Cell Cultures
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[Genotyping of CYP2D6 and CYP2C19]

O Slanar1, M Drazd'áková, K Babiárová

  • 1Ustav klinické biochemie a laboratorní diagnostiky 1. LF UK a VFN, Praha 2 0dd4lenf klinicke farmakologie 1. LF UK a VFN, Praha. oslan@lf1.cuni.cz

Casopis Lekaru Ceskych
|October 31, 2007
PubMed
Summary

Genetic variations in CYP2D6 enzyme activity significantly impact drug response. Patients experiencing adverse drug reactions or treatment failure showed fewer extensive CYP2D6 metabolizers compared to healthy individuals.

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