Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bacterial Phylum Spirochaetes

Bacterial Phylum Spirochaetes

Spirochetes, unique bacteria in the phylum Spirochaetes, are gram-negative, motile, tightly coiled, slender, and flexible. They inhabit aquatic sediments and animals, with some causing diseases like syphilis. Spirochetes are classified into eight genera based on habitat, pathogenicity, phylogeny, and characteristics.Their distinctive motility arises from endoflagella, located within the cell’s periplasm. These endoflagella anchor at the cell poles and extend along the cell length, encased by a...

Leishmaniasis

Leishmaniasis

Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...

Rabies

Rabies

Rabies is a lethal zoonotic disease caused by a single-stranded, negative-sense RNA virus of the Lyssavirus genus, within the family Rhabdoviridae. Its primary mode of transmission to humans is through bites or saliva-contaminated scratches from infected mammals such as dogs, bats, raccoons, or foxes. Transmission can also occur if infectious saliva contacts abraded skin or intact mucous membranes, including the conjunctiva.Viral Entry and Early ReplicationOnce introduced at the bite or scratch...

Antiprotozoal Agents

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...

Toxoplasmosis

Toxoplasmosis

Toxoplasmosis, a zoonotic disease caused by the protozoan Toxoplasma gondii, poses significant public health challenges globally due to its high seroprevalence and varied clinical manifestations. As an obligate intracellular parasite, T. gondii can infect all warm-blooded vertebrates, but felids are its only definitive hosts, shedding unsporulated oocysts into the environment. Humans typically acquire the infection through ingestion of tissue cysts in undercooked meat or oocysts from...

Disorders of Leukocytes

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Examining aphasia rehabilitation in Colombia from the perspective of speech-language pathologists and neuropsychologists: a pilot study.

Aphasiology·2026

Same author

<i>"You're never going to get a second chance if someone doesn't give you a second chance"</i> perspectives and experiences of landlords and advocates on implementing HOME among youth experiencing homelessness.

Frontiers in public health·2025

Same author

Waistline Aesthetic Slimming by Puncture and Parallel Approach for Rib Remodeling Procedures.

Aesthetic surgery journal. Open forum·2025

Same author

Ultrasound-Guided Female Equilibrated Minimal Muscularization and Enhancement (U-Femme).

Aesthetic surgery journal. Open forum·2025

Same author

Well-Child and Hematology Visit Adherence Among Youth With Sickle Cell Disease.

Pediatrics·2025

Same author

A Practical Guide to Assessing and Addressing Context in Quality Improvement.

Hospital pediatrics·2025

Search research articles

Related Experiment Video

Updated: Jul 10, 2026

Polymerase Chain Reaction and Dot-Blot Hybridization for Leptospira Detection in Water Samples

Polymerase Chain Reaction and Dot-Blot Hybridization for Leptospira Detection in Water Samples

Published on: June 14, 2024

[Leptospira, does it simulate or cause leukemia?].

Oscar Velasco-Castrejón¹, Beatriz Rivas-Sánchez, Esther Gutiérrez

¹Laboratorio de Medicina Tropical, Unidad Medicina Experimental, Facultad de Medicina, UNAM - Hospital General de México. oscarvel1@yahoo.com

Revista Cubana De Medicina Tropical

|October 31, 2007

Summary

Leptospirosis can mimic leukemia, causing bleeding disorders. Early detection using specialized stains and immunofluorescence in bone marrow is crucial for effective treatment and public health awareness.

More Related Videos

High-throughput Parallel Sequencing to Measure Fitness of Leptospira interrogans Transposon Insertion Mutants During Golden Syrian Hamster Infection

High-throughput Parallel Sequencing to Measure Fitness of Leptospira interrogans Transposon Insertion Mutants During Golden Syrian Hamster Infection

Published on: December 18, 2017

A Modular Workflow for Quantitative, Structural and Functional Analysis of Leptospira Biofilms

A Modular Workflow for Quantitative, Structural and Functional Analysis of Leptospira Biofilms

Published on: December 19, 2025

Related Experiment Videos

Last Updated: Jul 10, 2026

Polymerase Chain Reaction and Dot-Blot Hybridization for Leptospira Detection in Water Samples

Polymerase Chain Reaction and Dot-Blot Hybridization for Leptospira Detection in Water Samples

Published on: June 14, 2024

High-throughput Parallel Sequencing to Measure Fitness of Leptospira interrogans Transposon Insertion Mutants During Golden Syrian Hamster Infection

High-throughput Parallel Sequencing to Measure Fitness of Leptospira interrogans Transposon Insertion Mutants During Golden Syrian Hamster Infection

Published on: December 18, 2017

A Modular Workflow for Quantitative, Structural and Functional Analysis of Leptospira Biofilms

A Modular Workflow for Quantitative, Structural and Functional Analysis of Leptospira Biofilms

Published on: December 19, 2025

Area of Science:

Hematology
Infectious Diseases
Pathology

Background:

Leptospirosis is an infectious disease caused by Leptospira spirochetes.
It can present with diverse clinical manifestations, sometimes mimicking hematological malignancies.

Observation:

Two patients with bicytopenia and pancytopenia, respectively, presented with bleeding and were initially diagnosed with leukemia.
Despite treatment for leukemia, one patient improved significantly with high-dose penicillin.
Histopathology revealed leptospires in bone marrow and other organs, not neoplastic cells.

Findings:

The histopathological diagnoses were generalized leptospirosis with medullary aplasia and myelodysplastic syndrome.
Leptospira infection was confirmed via Warthin-Starry staining and immunofluorescence.
The study suggests Leptospira may induce leukemoid reactions or be misdiagnosed as leukemia.

Implications:

Hematologists and pathologists should consider leptospirosis in patients with unexplained cytopenias and bleeding.
Advanced diagnostic techniques like silver staining and immunofluorescence are vital for detecting leptospires, especially in seronegative cases.
Accurate diagnosis of leptospirosis is essential for effective treatment and public health surveillance, challenging the perceived low impact of this spirochetosis.