Related Experiment Video
Updated: Jul 10, 2026
06:19
A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis
Published on: January 7, 2018
[Umbilical cord constriction caused by amniotic band]
Mette Krogh Voss1, Lis Saxtoft Hansen, Kjeld Leisgård Rasmussen
1Rasmussen Regionshospitalet Herning, Gynaekologisk-obstetrisk Afdeling. mettekvoss@hotmail.com
Ugeskrift for Laeger
|October 31, 2007
Summary
Amniotic bands can fatally constrict umbilical cords, a rare event affecting 1 in 100,000 births. Prenatal diagnosis via ultrasound and MRI is possible, with fetoscopic surgery as a potential treatment.
Area of Science:
- Perinatology
- Fetal Medicine
- Reproductive Biology
Background:
- Umbilical cord constriction by amniotic bands is a rare but potentially fatal obstetric complication.
- This condition occurs in approximately 1 in 100,000 to 150,000 births.
- Early diagnosis and intervention are crucial for improving fetal outcomes.
Observation:
- A case of fatal umbilical cord constriction due to an amniotic band is presented.
- The constriction led to a fatal outcome for the fetus.
- This highlights the severe consequences of untreated amniotic band syndrome.
Findings:
- Prenatal diagnosis of umbilical cord constriction is achievable using ultrasonography and magnetic resonance imaging (MRI).
- These advanced imaging techniques allow for timely identification of the condition before labor.
- The findings underscore the importance of routine prenatal screening for potential cord abnormalities.
Implications:
- Fetoscopic surgical removal of the amniotic band represents the only theoretically viable therapeutic option.
- Prompt diagnosis and potential surgical intervention could offer a chance to prevent fetal demise.
- Further research into the efficacy and safety of fetoscopic interventions for this condition is warranted.
Related Concept Videos
01:14Fetal Circulation
Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
01:07Intestinal Obstruction II: Pathophysiology
Intestinal obstruction triggers a series of physiological responses, starting with gas and fluid accumulation in the bowel segment proximal to the obstruction, leading to distension. This distended intestine compresses the diaphragm, hindering lung expansion and potentially leading to reduced respiratory effort, atelectasis, and pneumonia.To overcome the blockage, the gut intensifies contractions, causing colicky abdominal pain, nausea, and vomiting, which reduces fluid and food intake and...
01:20Embryonic Connective Tissues
During early development, the embryo forms two types of connective tissues— the mesenchyme and mucoid connective tissue.
The mesenchyme is the first connective tissue that emerges in the developing embryo. It consists of loosely arranged multipotent mesenchymal cells and reticular fibers in the extracellular matrix. This loose arrangement allows easy migration of cells, which is essential for germ layer positioning, patterning, and organ morphogenesis during embryonic development. Mesenchyme is...
The mesenchyme is the first connective tissue that emerges in the developing embryo. It consists of loosely arranged multipotent mesenchymal cells and reticular fibers in the extracellular matrix. This loose arrangement allows easy migration of cells, which is essential for germ layer positioning, patterning, and organ morphogenesis during embryonic development. Mesenchyme is...
01:07Development of Blood Vessels
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
01:07Teratogenicity
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
02:15The Contractile Ring
Contractile rings are composed of microfilaments and are responsible for separating the daughter cells during cytokinesis. Contractile ring assembly proceeds along with other cell cycle events; however, very few mechanistic details are known about the timing and coordination of the contractile rings with the cell cycle.
A small GTPase, RhoA, controls the function and assembly of the contractile ring. RhoA belongs to the Ras superfamily of proteins. The activation of formins by RhoA promotes...
A small GTPase, RhoA, controls the function and assembly of the contractile ring. RhoA belongs to the Ras superfamily of proteins. The activation of formins by RhoA promotes...