[Eosinophilic cystitis as a special form of response to mitomycin C. Analysis and comments on our cases]

We analyzed 29 cases of eosinophilic cystitis in a group of 80 patients with lower urothelial carcinoma who had been treated with mitomycin-C. Only 6 cases (20.7%) had presented symptoms and signs compatible with acute cystitis. The remaining patients had been diagnosed histopathologically by routine follow-up bladder biopsy. Urine cytology revealed abundant eosinophils in 58.6% of the patients with eosinophilic cystitis while urine culture was negative for all patients. No patient had a previous history of allergy or asthma. We discuss the possible etiopathogenic mechanisms of this rare nosologic entity, the relationship to the immune system and the role of the foregoing in the capacity to control urothelial carcinoma locally.