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MRI of regular-shaped cell-encapsulating polyhedral microcontainers.

Barjor Gimi1, Dmitri Artemov, Timothy Leong

  • 1Department of Radiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235, USA. barjorg@yahoo.com

Magnetic Resonance in Medicine
|October 31, 2007
PubMed
Summary

Researchers developed novel cubic and pyramidal microcontainers for cell encapsulation. Magnetic Resonance Imaging (MRI) techniques were used for noninvasive detection and tracking of these microcontainers in vivo.

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Area of Science:

  • Biomaterials Engineering
  • Medical Imaging
  • Cell Encapsulation Technology

Background:

  • Cell encapsulation requires microcontainers for protection and controlled release.
  • Noninvasive imaging is crucial for tracking implanted biomaterials and guiding therapies.
  • Current imaging methods may lack the resolution or contrast for specific microcontainer applications.

Purpose of the Study:

  • To develop and characterize novel cubic and pyramidal microcontainers for cell encapsulation.
  • To demonstrate noninvasive Magnetic Resonance Imaging (MRI) techniques for detecting and localizing these microcontainers in vivo.
  • To evaluate different MRI contrast mechanisms for microcontainer imaging.

Main Methods:

  • Fabrication of cubic and pyramidal microcontainers.

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  • Cell encapsulation within microcontainers.
  • Noninvasive imaging using Magnetic Resonance Imaging (MRI) with diamagnetic and ferromagnetic materials.
  • Evaluation of negative and positive contrast imaging techniques.

    • Main Results:

    • Pyramidal microcontainers offer a higher surface area-to-volume ratio than cubic ones.
    • Noninvasive MRI successfully detected and localized microcontainers using RF shielding (negative contrast).
    • Positive contrast MRI was achieved for diamagnetic microcontainers.
    • In vivo negative-contrast MRI visualized ferromagnetic microcontainers, creating contrast regions larger than the microcontainers themselves.

    Conclusions:

    • Cubic and pyramidal microcontainers are suitable for cell encapsulation.
    • MRI provides a versatile, noninvasive method for detecting and tracking microcontainers in vivo.
    • Tailored MRI contrast strategies (negative/positive, diamagnetic/ferromagnetic) enable imaging of microcontainers for various applications, including image-guided therapy.