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High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
Published on: March 24, 2015
Interferon research: impact on understanding transcriptional control
1Laboratory of Molecular Cell Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA. darnell@rockefeller.edu
Current Topics in Microbiology and Immunology
|November 1, 2007
Summary
The 50th anniversary of interferon discovery is celebrated. This antiviral substance
Area of Science:
- Immunology
- Virology
- Molecular Biology
Background:
- The 50th anniversary of the Isaacs/Lindenmann discovery of interferon marks a significant milestone.
- Interferon, a secreted substance of cellular origin, confers resistance against diverse viruses.
- The discovery of signal transducer and activator of transcription (STATs) and Jak kinases was stimulated by interferon research.
Purpose of the Study:
- To reflect on the discovery of interferon and its impact.
- To discuss the subsequent discovery of STATs and Jak kinases.
- To explore the role of transcription in cellular responses.
Main Methods:
- Historical review of interferon research.
- Discussion of molecular mechanisms of interferon action.
- Exploration of signal transduction pathways.
Main Results:
- Interferon discovery provided a key antiviral defense mechanism.
- The study of interferon led to the identification of STATs and Jak kinases.
- These findings deepened the understanding of how transcription regulates cell behavior.
Conclusions:
- The discovery of interferon has had a profound impact on virology and immunology.
- Interferon research continues to yield significant insights into cellular signaling and gene regulation.
- Further exploration of these pathways holds promise for therapeutic interventions.
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