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Updated: Jul 10, 2026

Retroductal Submandibular Gland Instillation and Localized Fractionated Irradiation in a Rat Model of Salivary Hypofunction
Published on: April 24, 2016
[Radiation-induced xerostomia: prevention, treatment, perspectives]
N Guinand1, P Dulguerov, R Giger
1Service d'oto-rhino-laryngologie et de chirurgie cervico-faciale HUG, 1211 Genève. Nils.Guinand@hcuge.ch
Abstract:
Most of head and neck cancer patients will undergo radiotherapy. Xerostomia is probably its most frequent side effect. Subjective and objective criteria allow evaluating and grading xerostomia. New radiotherapy techniques and use of cytoprotectants can help to preserve salivary gland function. Parasym-pathicomimetics and saliva substitutes reduce symptoms. Strict mouth cleaning and fluoride's use prevent teeth deterioration and infections. Important breakthroughs have been made in the pathophysiology of xerostomia and new treatments are developed.
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