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Published on: October 10, 2012
Therapeutic effects of glyprolines (PGP, GP, and PG) in rats with stress-induced behavioral disorders
G N Kopylova1, Z V Bakaeva, S E Badmaeva
1Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University. kopylovagn@list.ru
Bulletin of Experimental Biology and Medicine
|November 1, 2007
Abstract:
Experiments on male outbred albino rats showed that stress (10-min swimming) increased anxiety and inhibited orientation and exploratory activities. Poststress (15 min after the end of swimming) intranasal administration of peptides Pro-Gly-Pro and Gly-Pro in a dose of 3.7 micromol/kg prevented stress-induced behavioral disorders. This effect persisted for 3 h.
