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Related Concept Videos

Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

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Related Experiment Video

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Investigating Intestinal Inflammation in DSS-induced Model of IBD
08:43

Investigating Intestinal Inflammation in DSS-induced Model of IBD

Published on: February 1, 2012

Basic research on inflammatory bowel disease in China.

Ai Ping Bai1, Qin Ouyang, Ren Wei Hu

  • 1Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.

Journal of Digestive Diseases
|November 1, 2007
PubMed
Summary
This summary is machine-generated.

Basic research on inflammatory bowel disease (IBD) in China is limited but growing. Studies predominantly focus on immunological mechanisms and traditional Chinese medicine

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Area of Science:

  • Gastroenterology
  • Immunology
  • Pharmacology

Background:

  • The etiology and pathogenesis of inflammatory bowel disease (IBD) remain incompletely understood.
  • Research efforts globally and in China aim to elucidate the underlying mechanisms of IBD.

Purpose of the Study:

  • To analyze the progress of basic research on inflammatory bowel disease (IBD) in Chinese medical journals from 1989 to 2003.
  • To identify key research trends and focus areas within IBD basic science in China during the specified period.

Main Methods:

  • A comprehensive review and analysis of basic science investigative papers on IBD.
  • Searches were conducted in Chinese periodicals (VIP and CMCC) using keywords: inflammatory bowel disease, ulcerative colitis, Crohn's disease, basic science investigation, and literature review.
  • Papers published between 1989 and 2003 were included.

Main Results:

  • A total of 3454 articles on IBD were published, with 508 focusing on basic scientific investigations over 15 years.
  • Pathogenesis was investigated in 463 papers, immunological mechanisms in 287, and other mechanisms in 176.
  • 142 papers explored traditional Chinese medicine's mechanisms on IBD, including 117 animal experiments and 25 clinical studies.

Conclusions:

  • The volume of basic investigative papers on IBD in Chinese journals is relatively low but indicates increasing emphasis on IBD research in China.
  • Research on immunological mechanisms constitutes the predominant area of basic IBD investigation.
  • A significant portion of research has focused on the mechanisms and effects of traditional Chinese medicine in managing IBD.