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07:48
An Orthotopic Bladder Cancer Model for Gene Delivery Studies
Published on: December 1, 2013
Declining mortality from bladder cancer in Europe.
Jacques Ferlay1, Giorgia Randi, Cristina Bosetti
1International Agency for Research on Cancer, Lyon Cedex, France.
BJU International
|November 1, 2007
Summary
Bladder cancer mortality is declining in most of Europe, especially in men, likely due to reduced smoking and occupational carcinogen exposure. Declines in women are less clear but may involve better infection control.
Area of Science:
- Epidemiology
- Public Health
- Oncology
Background:
- Bladder cancer mortality trends vary across Europe, with declines in Western Europe and increases in Central/Eastern Europe historically.
- Understanding current mortality patterns is crucial for public health interventions.
Purpose of the Study:
- To analyze updated bladder cancer mortality trends in 32 European countries and the European Union (EU) from 1970-2004.
- To identify geographical and temporal variations in bladder cancer mortality rates.
Main Methods:
- Utilized World Health Organization (WHO) database for mortality data (1970-2004).
- Employed join-point regression analysis to identify significant changes in mortality rates.
- Calculated age-standardized rates (world standard population) and truncated rates (age 35-64).
Main Results:
- Overall EU bladder cancer mortality stabilized until the early 1990s, then declined by ~16% in men and ~12% in women.
- Most countries showed decreasing trends, with exceptions in Croatia, Poland, Romania, and Denmark.
- Trends were more favorable in men, with a >21% decrease in the last decade for ages 35-64.
Conclusions:
- Favorable trends in men are linked to reduced smoking and occupational carcinogen exposure.
- Decreases in women's mortality are less understood, possibly influenced by better urinary tract infection control.
- The impact of diet and other urinary carcinogens on bladder cancer trends requires further investigation.
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