Related Experiment Video

Updated: Jul 10, 2026

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis
06:19

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis

Published on: May 16, 2025

Outcome of childhood ulcerative colitis at 2 years

L J Howarth1, A E Wiskin, D M Griffiths

  • 1Paediatric Medical Unit, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, United Kingdom.

Acta Paediatrica (Oslo, Norway : 1992)
|November 1, 2007
PubMed

Insights

Pediatric ulcerative colitis (UC) often requires early immunosuppression, with high azathioprine use by two years. Complications and extra-intestinal manifestations are common, and the colectomy rate is approximately 10%.

Area of Science:

  • Pediatric Gastroenterology
  • Inflammatory Bowel Disease Research
  • Clinical Outcomes in Pediatrics

Background:

  • Childhood ulcerative colitis (UC) incidence is 1.4 per 100,000.
  • Limited data exists on long-term outcomes, especially with early immunosuppression.
  • This study examines 2-year outcomes in pediatric UC patients.

Purpose of the Study:

  • To review the 2-year outcomes of pediatric ulcerative colitis.
  • To assess the need for immunosuppression in this cohort.
  • To identify complication rates and colectomy need.

Main Methods:

  • A consecutive cohort of 32 children diagnosed with UC between 2000-2003 was reviewed.
  • Exclusion criteria included indeterminate colitis.
  • Follow-up data was collected at 2 years via case notes.

Main Results:

  • Median age at diagnosis was 11 years.
  • 94% received multiple corticosteroid courses; 75% were on azathioprine by 2 years for steroid-dependent disease.
  • 12 patients (38%) experienced complications or extra-intestinal manifestations; 9% (3/32) required colectomy.

Conclusions:

  • Azathioprine is frequently required for pediatric UC.
  • The 2-year colectomy rate is around 10%.
  • Extra-intestinal manifestations and disease complications are prevalent.
Abstract

More Related Videos

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice08:20

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice

Published on: July 12, 2018

Related Concept Videos

Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...