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A novel triterpene from Centella asiatica.

Quan-Lin Yu1, Hong-Quan Duan, Yoshihisa Takaishi

  • 1College of Pharmaceutical Sciences and Biotechnology, Tianjin University, Tianjin 300072, PR China. quanlin_yu@yahoo.com.cn

Molecules (Basel, Switzerland)
|November 1, 2007
PubMed
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A new triterpene compound was identified from Centella asiatica. This compound showed no significant anticancer activity against Hela and A549 cell lines in preliminary tests.

Area of Science:

  • Natural Product Chemistry
  • Pharmacology

Background:

  • Centella asiatica is a medicinal plant with various bioactive compounds.
  • Triterpenes are a class of compounds known for diverse biological activities.

Purpose of the Study:

  • To isolate and characterize a novel triterpene from Centella asiatica.
  • To evaluate the cytotoxic activity of the isolated compound against cancer cell lines.

Main Methods:

  • Isolation of the compound using chromatographic techniques.
  • Structure elucidation using spectroscopic methods, including 2D-NMR.
  • In vitro cytotoxic assay against Hela and A549 cell lines.

Main Results:

  • A novel triterpene, 2alpha,3beta,20,23-tetrahydroxyurs-28-oic acid (1), was successfully isolated.

Related Experiment Videos

  • The structure of compound (1) was confirmed through comprehensive spectroscopic analysis.
  • Compound (1) exhibited no cytotoxic activity against Hela and A549 cells at tested concentrations.

    • Conclusions:

    • The novel triterpene 2alpha,3beta,20,23-tetrahydroxyurs-28-oic acid (1) was identified from Centella asiatica.
    • The isolated compound does not possess significant cytotoxic effects on Hela and A549 cell lines under the tested conditions.