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Chronic kidney disease definition and classification: the quest for refinements
1Renal Section, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA. geknoyan@bcm.edu
Kidney International
|November 2, 2007
Summary
The current definition of chronic kidney disease (CKD) needs revision. Changing the chronicity criterion impacts staging but does not reduce the high mortality risk associated with CKD.
Area of Science:
- Nephrology
- Epidemiology
- Public Health
Background:
- The current definition and staging of chronic kidney disease (CKD) have facilitated research into its epidemiology, course, outcomes, and burden.
- The established 3-month chronicity criterion is a cornerstone of CKD diagnosis and classification.
Discussion:
- Eriksen and Ingebretsen propose modifying the 3-month chronicity criterion for CKD.
- Altering chronicity duration impacted patient counts in stages 3 and 4 but did not reduce overall mortality.
- Chronic kidney disease remains a substantial risk multiplier for mortality, irrespective of staging adjustments.
Key Insights:
- Revising CKD chronicity criteria does not mitigate its association with increased mortality.
- CKD's role as a predictor of death persists despite changes in diagnostic duration.
- The fundamental burden of CKD on patient survival remains a critical concern.
Outlook:
- Further research is needed to refine CKD staging and understand its impact on mortality.
- Investigating alternative biomarkers or criteria may be necessary to better predict CKD outcomes.
- Focus should remain on managing CKD to reduce its significant mortality risk.
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