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DNA cleavage function of seryl-histidine dipeptide and its application.

Y Ma1, X Chen, M Sun

  • 1The Key Laboratory of Bioorganic Phosphorus and Chemical Biology, Department of Chemistry, Tsinghua University, Beijing, China. mayuan@mail.tsinghua.edu.cn

Amino Acids
|November 2, 2007
PubMed
Summary

The Ser-His dipeptide cleaves DNA by breaking phospho-diester bonds. This specific amino acid sequence is vital for DNA cleavage and may have influenced early enzyme evolution.

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