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Static lung volumes in patients with Cushing's disease

A D Azezli1, T Bayraktaroglu, T Ece

  • 1Department of Internal Medicine, Division of Endocrinology and Metabolism, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [And] German Diabetes Association
|November 2, 2007
PubMed

Insights

Pulmonary function tests, including spirometry, were normal in patients with Cushing's disease (CD). This study found no significant lung volume or ventilatory performance disturbances in active CD.

Area of Science:

  • Endocrinology
  • Pulmonology
  • Internal Medicine

Background:

  • Cushing's syndrome presents with diverse clinical manifestations.
  • Pulmonary function data in Cushing's disease (CD) are notably absent.
  • This study addresses the gap in understanding respiratory function in CD.

Purpose of the Study:

  • To assess pulmonary function tests, specifically spirometry, in patients with active Cushing's disease.
  • To evaluate lung volumes and ventilatory performance in individuals with endogenous hypercortisolism.

Main Methods:

  • A cross-sectional study involving 10 patients diagnosed with active Cushing's disease.
  • Spirometry was performed to measure forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), FEV1/FVC ratio, and FEF 25-75%.

Main Results:

  • No spirometric abnormalities were detected in the study cohort.
  • No significant differences were observed when comparing patient values to reference values.
  • Disease duration and cortisol levels showed negative correlations with specific spirometry parameters.

Conclusions:

  • Lung volumes and ventilatory performance, as assessed by spirometry, are not impaired in patients with Cushing's disease.
  • Endogenous hypercortisolism in CD does not appear to significantly affect standard pulmonary function measures.
Abstract

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