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Updated: Aug 12, 2025
04:39
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
1.8K
GRANULYSIN PEPTIDE AND GENE POLYMORPHISM IN THE PATHOGENESIS OF HASHIMOTO THYROIDITIS
G Cakmak Genc1, S Karakas Celik2, D Arpaci3
1Zonguldak Bülent Ecevit University Training and Research Hospital, Dept. of Medical Genetics, Zonguldak, Turkey.
Acta Endocrinologica (Bucharest, Romania : 2005)
|January 26, 2023
Summary
This study found no significant association between granulysin (GNLY) levels or GNLY gene polymorphisms and Hashimoto thyroiditis (HT). These factors do not appear to contribute to the autoimmune thyroid disease.
Area of Science:
- Immunology
- Genetics
- Endocrinology
Background:
- Hashimoto thyroiditis (HT) is an autoimmune disorder causing hypothyroidism due to thyroid cell destruction.
- Granulysin (GNLY), a cytolytic peptide, is implicated in various diseases, but its role in HT is understudied.
Purpose of the Study:
- To investigate the potential contribution of granulysin levels and GNLY gene polymorphisms to the immune response in Hashimoto thyroiditis.
Main Methods:
- Genotyping of GNLY rs10180391 and rs7908 polymorphisms using PCR-RFLP.
- Quantification of serum granulysin levels via ELISA.
- Comparison between 100 HT patients and 140 healthy controls.
Main Results:
- No statistically significant differences were observed in genotype or allele frequencies of GNLY polymorphisms between HT patients and controls.
- Serum granulysin levels did not differ significantly between the patient and control groups.
Conclusions:
- Granulysin levels and GNLY gene polymorphisms are not associated with Hashimoto thyroiditis.
- These findings suggest GNLY is unlikely to be a significant factor in the pathogenesis of HT.
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