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Related Experiment Video

Updated: Jan 15, 2026

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THYROID NODULE FREQUENCY AND MALIGNANCY RISK ACCORDING TO ATA- 2015 AND ACR-TI-RADS CLASSIFICATION IN OBESE PATIENTS.

Z Yarar1, H Çalişkan Burgucu2, M Can3

  • 1Department of Internal Medicine, Division of Endocrinology and Metabolism, Tokat State Hospital, Tokat.

Acta Endocrinologica (Bucharest, Romania : 2005)
|October 10, 2025
PubMed
Summary

Obesity is linked to a higher prevalence of thyroid nodules. However, obesity does not increase the malignancy risk of these thyroid nodules, according to established ultrasonographic classification systems.

Keywords:
Thyroid noduleobesitythyroid ultrasonography

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Area of Science:

  • Endocrinology
  • Radiology
  • Oncology

Background:

  • Obesity is a growing global health concern.
  • Thyroid nodules are common, and their evaluation relies on imaging and risk stratification.
  • Understanding the relationship between obesity and thyroid nodule characteristics is crucial for clinical management.

Purpose of the Study:

  • To compare thyroid nodule ultrasound findings, frequency, and malignancy risk between obese and non-obese individuals.
  • To evaluate the utility of the American Thyroid Association (ATA) and American College of Radiology Thyroid Imaging Reporting and Data System (ACR-TIRADS) in assessing nodules in these groups.

Main Methods:

  • A comparative study included 111 obese subjects and 111 age- and sex-matched non-obese controls.
  • Thyroid nodule malignancy risk was assessed using ATA and ACR-TIRADS classification systems.
  • Fine needle aspiration biopsy (FNAB) and cytopathological evaluation (Bethesda system) were performed on suspicious nodules.

Main Results:

  • No significant differences were observed in age, sex, TSH levels, or thyroid volumes between the groups.
  • Thyroid nodules were detected in 32.4% of obese subjects versus 19.8% of controls (p=0.046).
  • The malignancy risk of thyroid nodules did not differ between obese and non-obese subjects based on ultrasonographic classifications.

Conclusions:

  • Obese individuals exhibit a higher frequency of thyroid nodules compared to non-obese individuals.
  • Ultrasonographic classification systems (ATA and ACR-TIRADS) indicate no increased malignancy risk for thyroid nodules in obese patients.
  • Further research may explore the underlying mechanisms linking obesity to increased nodule prevalence without altering malignancy potential.