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Updated: Jul 10, 2026
12:23
Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Cutaneous granulomas in rheumatoid arthritis
Esther J H Collaris1, Ariënne M W van Marion, Jorge Frank
1Department of Dermatology, University Hospital Maastricht, The Netherlands. ecola@sder.azm.nl
International Journal of Dermatology
|December 6, 2007
Summary
Palisaded neutrophilic granulomatous dermatitis (PNGD) is an uncommon skin condition. This case report highlights PNGD in a patient with rheumatoid arthritis and myasthenia gravis, discussing its clinical and histological features.
Area of Science:
- Dermatology
- Rheumatology
- Neurology
Background:
- Rheumatoid arthritis and myasthenia gravis are chronic autoimmune conditions.
- Cutaneous manifestations can occur in collagen vascular disorders.
- Palisaded neutrophilic granulomatous dermatitis (PNGD) is a rare dermatosis.
Observation:
- A 57-year-old man presented with an asymptomatic nasal plaque and elbow nodules.
- The patient had a history of rheumatoid arthritis and myasthenia gravis.
- Histopathology revealed findings suggestive of PNGD.
Findings:
- PNGD is characterized by specific histopathological features, including palisaded neutrophils.
- The condition can present with diverse clinical appearances.
- PNGD is associated with various collagen vascular and autoimmune diseases.
Implications:
- This case expands the understanding of PNGD's clinical spectrum.
- Early recognition of PNGD is crucial for managing associated systemic conditions.
- Further research is needed to elucidate the pathogenesis of PNGD in autoimmune disorders.
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