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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Personality Disorders: Paranoid and Schizoid01:22

Personality Disorders: Paranoid and Schizoid

Personality disorders represent enduring cognition, affect, and behavior patterns that significantly deviate from societal norms. These maladaptive traits often lead to difficulties in various domains, including interpersonal relationships, occupational settings, and overall psychological well-being. Paranoid personality disorder and schizoid personality disorder are two distinct conditions marked by odd or eccentric behavior.
Paranoid Personality Disorder
Paranoid personality disorder is...
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...

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Related Experiment Video

Updated: Jul 10, 2026

Measuring Psoriasis Severity at Home
02:28

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

Parapsoriasis: a complex issue.

Virendra N Sehgal1, Govind Srivastava, Ashok K Aggarwal

  • 1Dermato-Venereology (Skin/VD) Centre, Sehgal Nursing Home, Panchwati, Azadpur, New Delhi, India. drsehgal@ndf.vsnl.net.in

Skinmed
|November 3, 2007
PubMed
Summary

Parapsoriasis presents a spectrum of skin reactions, from small to large plaques, including pityriasis lichenoides and lymphomatoid papulosis. Understanding these conditions aids diagnosis and highlights potential links to future neoplasms.

Related Experiment Videos

Last Updated: Jul 10, 2026

Measuring Psoriasis Severity at Home
02:28

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

Area of Science:

  • Dermatology
  • Pathology

Background:

  • Parapsoriasis encompasses a range of skin conditions with clinical presentations varying from small plaque parapsoriasis to large plaque parapsoriasis.
  • The spectrum includes pityriasis lichenoides, pityriasis lichenoides chronica, pityriasis lichenoides et varioliformis acuta, and lymphomatoid papulosis, bridging the clinical gap between the two ends.

Purpose of the Study:

  • To elucidate the clinical patterns of parapsoriasis spectrum diseases for improved recognition in dermatologic practice.
  • To review the potential etiopathogenesis of these conditions based on current literature.
  • To emphasize the importance of follow-up due to the risk of developing true neoplasms.

Main Methods:

  • Clinical pattern elucidation.
  • Literature review on etiopathogenesis.
  • Discussion of treatment modalities.

Main Results:

  • The study provides a clear overview of the clinical manifestations of the parapsoriasis spectrum.
  • It highlights the diagnostic challenges and the need for careful clinical assessment.
  • The potential for malignant transformation in some cases is underscored.

Conclusions:

  • Accurate recognition of the parapsoriasis spectrum is crucial for appropriate patient management.
  • Ongoing research into etiopathogenesis may refine understanding and treatment.
  • Vigilant follow-up is essential to monitor for neoplastic progression.