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Related Experiment Video

Updated: Jul 10, 2026

Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins
09:12

Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins

Published on: January 18, 2019

Contrast-induced nephropathy.

Tereza Pucelikova1, George Dangas, Roxana Mehran

  • 1Cardiovascular Research Foundation, 55 East 59th Street, 6th Floor, New York, New York 10022, USA.

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
|November 3, 2007
PubMed
Summary
This summary is machine-generated.

Contrast induced nephropathy (CIN), a kidney injury from contrast media, affects high-risk patients. Prevention focuses on hydration and identifying those susceptible to contrast-induced nephropathy.

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Last Updated: Jul 10, 2026

Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins
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Area of Science:

  • Nephrology
  • Radiology
  • Pharmacology

Background:

  • Contrast induced nephropathy (CIN) is an iatrogenic kidney disorder caused by contrast media.
  • Pathogenesis involves hemodynamic and cytotoxic effects, with other mechanisms less understood.
  • CIN is defined by serum creatinine increase (> or =0.5 mg/dl or > or =25%) within 2-3 days post-contrast.

Purpose of the Study:

  • To review the pathogenesis, risk factors, and prevention strategies for contrast induced nephropathy.
  • To highlight current clinical practices in managing patients at risk for CIN.

Main Methods:

  • Literature review of CIN pathogenesis, risk factors, and prevention.
  • Analysis of diagnostic criteria and current clinical recommendations.

Main Results:

  • CIN incidence is higher in patients with renal disorders, diabetes, and the elderly.
  • Risk factors for CIN are synergistic.
  • Peri-procedural hydration and identifying at-risk patients are key preventive measures.

Conclusions:

  • The role of prophylactic drugs for CIN prevention requires further investigation.
  • Non-ionic low-osmolar contrast media are preferred for patients with renal impairment.