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Advancements in immune tolerance.

Ping-Ying Pan1, Junko Ozao, Zuping Zhou

  • 1Department of Gene and Cell Medicine, Mount Sinai School od Medicine, New York, NY 10029, USA. ping-ying.pan@mssm.edu

Advanced Drug Delivery Reviews
|November 3, 2007
PubMed
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This review explores immune tolerance and tolerogenic cell therapy for treating diseases and preventing transplant rejection. It highlights how understanding and manipulating these cells offers promising clinical applications.

Area of Science:

  • Immunology
  • Cell Therapy
  • Clinical Applications

Background:

  • Immune tolerance is crucial for preventing autoimmune diseases and transplant rejection.
  • Recent advances have deepened our understanding of immune tolerance mechanisms.
  • Cell-based tolerogenic therapy is a rapidly advancing field with significant clinical potential.

Purpose of the Study:

  • To review major tolerogenic cell populations and their mechanisms.
  • To focus on the clinical applications of immune tolerance.
  • To discuss the potential of cell-based tolerogenic therapy.

Main Methods:

  • Review of existing literature on immune tolerance.
  • Analysis of experimental settings and animal models.
  • Evaluation of in vitro and in vivo manipulation of tolerogenic cells.

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Main Results:

  • Identification of key tolerogenic cell populations.
  • Elucidation of their mechanisms of action.
  • Assessment of their therapeutic potential in various diseases and transplantation.

Conclusions:

  • Harnessing immune tolerance through cell-based therapy holds promise for treating cancers, autoimmune diseases, and preventing transplant complications.
  • Further research into manipulating tolerogenic cells can accelerate clinical translation.
  • Cellular therapies offer a novel approach to immune modulation for therapeutic benefit.