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Published on: March 11, 2014
Pap smears with reactive cellular changes: a prospective study
Dah-Ching Ding1, Senzan Hsu, Sidney S Chen
1Department of Obstetrics and Gynecology, Buddhist Tzu Chi General Hospital, and Graduate Institute of Medical Science, School of Medicine, Tzu Chi University, Hualien, Taiwan, ROC. dah1003@yahoo.com.tw
Objective:
To determine the prevalence of cervical dysplasia and cervical cancer in women with atypical squamous cells (ASCs).
Study Design:
A prospective study was conducted at Buddhist Tzu Chi General Hospital from January 1 to September 30, 2003. The primary measurement was cervical dysplasia and the secondary one, cervical cancer. Forty-nine women with Pap smears showing reactive cellular changes were enrolled. All patients underwent colposcopy and biopsy. Endocervical curettage (ECC) was performed before colposcopy. All specimens were reviewed by a pathologist.
Results:
Histologic results revealed normal findings in 30 (61%), mild dysplasia in 9 (18.3%), moderate dysplasia in 1 (2%), severe dysplasia in 2 (4%), squamous cell carcinoma in 2 (4%), adenocarcinoma in 1 (2%) and benign lesions in 4 (8.1%).
Conclusion:
Among the subjects with cervical ASCs, 30% and 6% with cervical dysplasia and cervical cancer, respectively, were identified. Colposcopically directed biopsy and ECC are warranted in women with ASC.
