Related Experiment Video
Updated: Jul 10, 2026
![Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60445.jpg&w=3840&q=50)
04:12
Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)
Published on: December 19, 2019
[Monoamines stimulations in experimental carcinogenesis].
Srpski Arhiv Za Celokupno Lekarstvo
|May 1, 1994
Summary
Piracetam, a psychoactive drug, significantly improved survival rates and reduced metastasis in tumor-bearing rats post-surgery. This suggests a potential antineoplastic effect linked to central nervous system monoamine modulation.
Area of Science:
- Neuroscience
- Oncology
- Pharmacology
Context:
- Central nervous system (CNS) monoamines play a role in cancerogenesis.
- Tumor development was induced in Wistar rats using 3-methylcholanthrene.
- Surgical tumor removal was performed when tumors reached 1-3 cm in size.
Purpose:
- To investigate the effect of Piracetam and cyclophosphamide on survival time in tumor-bearing rats after surgical tumor removal.
- To evaluate the incidence of metastasis in different treatment groups.
Summary:
- Piracetam treatment resulted in the longest survival time (81.2%) and the lowest incidence of metastases (87.1% without metastases).
- Cyclophosphamide treatment showed a survival time of 68.8% and 45.4% without metastases.
- Control group (surgery only) had 50% survival and 27.3% without metastases, with statistically significant differences observed.
Impact:
- Piracetam demonstrates a potential antineoplastic effect, possibly through neurotransmitter modulation affecting both CNS homeostasis and tumor cell processes.
- Findings suggest Piracetam's potential as an adjunct therapy in cancer treatment, warranting further investigation into its mechanisms.
Related Concept Videos
01:25Mutagenicity and Carcinogenicity
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
01:26Physical Properties of Amines
Amines with low molecular weight are usually gaseous at room temperature, while those with high molecular weight are liquid or solids in nature. Usually, low molecular weight amines have a rotten fish-like smell. Diamines typically have a pungent smell. For instance, cadaverine and putrescine, depicted in Figure 1, are two molecules responsible for decaying tissue.
01:15Drugs that Stabilize Microtubules
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
02:17The Tumor Microenvironment
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...