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Related Experiment Video

Updated: Jul 10, 2026

Experimental Investigation of the Flow Structure over a Delta Wing Via Flow Visualization Methods

Experimental Investigation of the Flow Structure over a Delta Wing Via Flow Visualization Methods

Published on: April 23, 2018

Evolution of the beta-propeller fold.

Indronil Chaudhuri¹, Johannes Söding, Andrei N Lupas

¹Department for Protein Evolution, Max Planck Institute for Developmental Biology, 72076 Tuebingen, Germany.

|November 6, 2007

Summary

beta-Propellers, a common protein fold in eukaryotes, likely share a common evolutionary origin. Analysis reveals mechanisms of amplification and differentiation are still active in their evolution.

Area of Science:

Protein structure and evolution
Bioinformatics and structural biology

Background:

beta-Propellers are toroidal protein folds with repeating beta-meander units, found across all life domains, particularly in eukaryotes.
Despite sequence diversity and classification into six structural groups (SCOP/CATH), propellers exhibit inter-group similarities suggesting a shared ancestry.

Purpose of the Study:

To investigate the evolutionary origins of beta-propeller protein folds.
To explore the mechanisms driving the diversification and evolution of beta-propellers.

Main Methods:

Analysis of sequence similarity using cluster mapping of all-beta folds.
Application of sensitive sequence comparison methods to assess homology.
Examination of genomic sequences for evidence of ongoing evolutionary mechanisms.

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Main Results:

A significant majority (45/60) of beta-propellers from the SCOP25 database cluster together based on sequence similarity, indicating homology.
Sensitive comparison methods confirmed similarity levels consistent with common ancestry across diverse propeller groups.
Genomic data revealed instances of nearly identical blades, supporting ongoing amplification and functional differentiation.

Conclusions:

The structural and sequence similarities strongly support a common evolutionary origin for most beta-propeller folds.
Protein evolution via amplification from single blades and subsequent functional differentiation is an ongoing process for beta-propellers.