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The immune status and response to measles vaccine amongst Egyptian infants. A preliminary report

S Abdel Hadi1, R Hassan, M Hosny

  • 1Department of Pediatrics, Cairo University.

The Journal of the Egyptian Public Health Association
|January 1, 1991
PubMed

Insights

Infants vaccinated at 9 months are susceptible to measles, but the Edmondston-Zagreb strain vaccine effectively induces immunity. Even infants with maternal antibodies show a good immune response post-vaccination.

Area of Science:

  • Pediatrics
  • Immunology
  • Vaccinology

Background:

  • Measles remains a significant public health concern globally.
  • Infant vaccination timing is critical for effective measles prevention.
  • Maternal antibodies can influence infant immune responses to vaccination.

Purpose of the Study:

  • To assess measles susceptibility in 9-month-old infants.
  • To evaluate the immunogenicity of the Edmonston-Zagreb measles vaccine strain.
  • To determine the impact of maternal antibodies on vaccine response.

Main Methods:

  • Study conducted on 18 infants in Giza Governorate.
  • Comprehensive history and physical examinations performed.
  • Measles antibody titers measured using neutralization testing before and after vaccination.

Main Results:

  • Infants vaccinated at 9 months demonstrated susceptibility to measles.
  • The Edmonston-Zagreb measles vaccine elicited a good immune response and conferred immunity.
  • Infants with persistent maternal antibodies responded well to vaccination.

Conclusions:

  • Current 9-month measles vaccination age may leave infants susceptible.
  • The Edmonston-Zagreb strain is effective in inducing immunity in infants.
  • Vaccination is beneficial even in the presence of maternal measles antibodies.

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