Related Experiment Videos
Prolonged release terbutaline sulphate microcapsules
N C Manekar1, P K Puranik, S B Joshi
1Department of Pharmaceutical Science, Nagpur University, India.
Journal of Microencapsulation
|October 1, 1991
Summary
Terbutaline sulphate microcapsules were developed using a novel solvent evaporation technique. These microcapsules demonstrated favorable characteristics for potential pharmaceutical applications.
Area of Science:
- Pharmaceutical Technology
- Materials Science
Background:
- Terbutaline sulphate is a bronchodilator used for respiratory conditions.
- Microencapsulation offers controlled release and improved drug delivery.
- Developing stable and effective microcapsule formulations is crucial for therapeutic efficacy.
Purpose of the Study:
- To prepare terbutaline sulphate microcapsules using the coacervation-phase separation technique.
- To evaluate the impact of cellulose acetate phthalate and ethyl cellulose as coating materials.
- To assess the physicochemical properties and in vitro dissolution of the prepared microcapsules.
Main Methods:
- Microencapsulation via coacervation-phase separation induced by solvent evaporation.
- Coating materials: cellulose acetate phthalate alone and in combination with ethyl cellulose.
- Evaluation of drug content, particle size, flow properties, bulk density, and in vitro dissolution.
Main Results:
- Successfully prepared terbutaline sulphate microcapsules with varying coating compositions.
- Characterization revealed specific particle size distributions and flow properties.
- In vitro dissolution studies indicated the release profile of terbutaline sulphate from the microcapsules.
Conclusions:
- The coacervation-phase separation technique is suitable for preparing terbutaline sulphate microcapsules.
- Coating materials influence the physicochemical properties and drug release.
- The developed microcapsules show potential for controlled delivery of terbutaline sulphate.