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Related Concept Videos

Catalysis01:27

Catalysis

Catalysis influences the rate of chemical reactions by providing an alternative reaction pathway with lower activation energy. A catalyst speeds up a reaction, but it is not consumed during the process. The fundamental principle of catalysis is the ability of a catalyst to alter the reaction mechanism, often introducing a more efficient pathway than the uncatalyzed process.In a catalyzed reaction, the catalyst participates directly in the reaction mechanism. It interacts with reactants to form...
Catalysis02:50

Catalysis

The presence of a catalyst affects the rate of a chemical reaction. A catalyst is a substance that can increase the reaction rate without being consumed during the process. A basic comprehension of a catalysts’ role during chemical reactions can be understood from the concept of reaction mechanisms and energy diagrams.
Clipper Circuit01:18

Clipper Circuit

A clipper circuit is a fundamental wave-shaping device that harnesses the unique properties of diodes to alter and control waveform characteristics. This technology is widely used in electronic devices, especially in television and radar communication systems, where it enhances waveform modulation in both transmitters and receivers.
The operation of a clipper circuit can be exemplified by analyzing a dual-clipper configuration setup that integrates two ideal diodes, each paired with a biasing...
Circles01:18

Circles

A circle in the coordinate plane is defined as the set of all points that lie at a constant distance, known as the radius, from a fixed point called the center. This relationship is captured using the distance formula. For a point (x, y) on the circle and a center (h, k), the distance between them equals the radius r. By squaring both sides of the distance formula, the equation of the circle is written in standard form:Constructing the Equation from Geometric InformationIf the center and the...
Affinity and Avidity01:41

Affinity and Avidity

Overview
Larynx01:21

Larynx

The human larynx, often referred to as the voice box, is an intricate organ located in the neck. It serves as a pathway for air to enter the lungs during respiration and is an essential component of voice production.
Anatomy of the Larynx
The larynx consists of various components, including cartilage, muscles, and vocal cords. Its structure includes three large unpaired cartilages—the thyroid, cricoid, and epiglottis—and three smaller paired cartilages—the arytenoids, corniculates, and...

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Related Experiment Video

Updated: Jul 10, 2026

Fluorescent In Situ Hybridization and 5-Ethynyl-2'-Deoxyuridine Labeling for Stem-Like Cells in the Hydrozoan Jellyfish Cladonema pacificum
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Published on: August 3, 2022

CYLD: a DUB with many talents.

Sara J S Simonson1, Zhao-Hui Wu1, Shigeki Miyamoto1

  • 1Department of Pharmacology, University of Wisconsin-Madison, 1300 University Avenue, Madison, WI 53706, USA.

Developmental Cell
|November 6, 2007
PubMed
Summary

The deubiquitinating enzyme CYLD suppresses tumors by inhibiting NF-kappaB pathways. New research shows CYLD is crucial for development by dismantling specific protein chains in vertebrates and invertebrates.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Developmental Biology

Background:

  • The deubiquitinating enzyme CYLD acts as a tumor suppressor.
  • CYLD is known to inhibit pro-oncogenic NF-kappaB signaling pathways.

Purpose of the Study:

  • To investigate the role of CYLD in dismantling polyubiquitin chains.
  • To determine the necessity of CYLD for normal development in various organisms.

Main Methods:

  • Analysis of CYLD's enzymatic activity on different polyubiquitin chain types.
  • Examination of developmental processes in CYLD-deficient models.

Main Results:

  • CYLD was shown to dismantle distinct types of polyubiquitin chains.
  • CYLD was found to be essential for normal vertebrate and invertebrate development.

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Conclusions:

  • CYLD's function extends beyond NF-kappaB inhibition to include critical roles in developmental processes.
  • The dismantling of specific polyubiquitin chains by CYLD is vital for organismal development.